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Wegovi’s weight-loss drug was approved by the US Food and Drug Administration (FDA) at the end of last week, describing the move as a “game changer”.

The drug, Wegovy, is used as a treatment to control weight loss, as it is injected weekly under the skin and is manufactured by the Danish pharmaceutical company Novo Nordisk.
Although this is the first FDA-approved weight-loss drug since 2014, it’s not exactly a new drug.

The same drug, also called semaglutide, has been used for years in the United States and elsewhere as an anti-diabetic drug. However, recent studies have shown that the drug, at a different and higher dosage, also acts as a powerful and effective appetite suppressant.

According to the Hebrew “Walla” website, the discovery of the long-term effects of the drug did not begin in one day, and the pharmaceutical companies that produced the smaglutide drug noted that while treating diabetic patients, patients lost weight.

The drug was usually administered to diabetic patients via moderate 3-4kg drops, leading the researchers to question whether the active ingredient could be used in higher doses. These drugs have been tested in large studies, and in addition to weight loss they have been found to reduce morbidity and mortality from cardiovascular disease.

In a study published earlier this year involving nearly 2,000 obese adults from 16 different countries, researchers reported that long-term treatment with the drug resulted in an average weight loss of about 15 percent in the group. Some of the participants even lost more weight, with more than 30 percent of the group losing more than 20 percent of their body weight – results that scientists describe as staggering.
How does Wegovi work?

“The Wigovy syringe given once a week works on several levels,” explains Dr. Alex Gorstein, an expert in endocrinology and diabetes at the Endocrinology Institute at Beilinson Hospital near Tel Aviv.

He added, “The first level is by increasing the secretion of insulin and suppressing appetite by affecting the satiety center. The second is to delay the passage of food through the stomach (this is important for diabetics). In addition, the drug has an anti-inflammatory effect. Nothing yet, but there are many drugs from the same family marketed under different names that we’ve been using for diabetes for a few years now.”
Who Can Medication Wegovee?

“Patients with a BMI greater than 30% or patients with a BMI greater than 27% and suffering from comorbidities such as fatty liver, blood pressure, diabetes, etc.”
Who can not use the drug?

Dr. Gorstein explains: “The drug may not be suitable for everyone. It is forbidden for patients with a previous history of pancreatitis, for patients with rare thyroid cancer or a related genetic syndrome, and for people who have problems with pancreatitis. If you have a chronic stomachache, we tend to be careful too.”
How much time do we need to see results?

“Results come quickly, within 10-12 weeks. The decrease in appetite occurs faster and within a month or two a person begins to lose weight.

Gorstein says that if a patient has not lost five percent of their weight after 3 months they should stop using the drug because it actually shows it isn’t right for them.
Do Wegove injections have side effects?

Most side effects are in the digestive system, and include symptoms such as nausea, abdominal discomfort, diarrhea or constipation. That is why we start with a small dose of the drug and increase the dose according to tolerance and side effects.

Side effects of the drug are common, and between 25-50 percent of patients experience them. These are mostly temporary symptoms that improve over time, and less than 10 percent stop treatment due to side effects.
What happens if you stop using it?

“This medication does not replace lifestyle changes such as eating a balanced diet and exercising,” Gorsain stresses.

“Once the treatment is stopped and no real changes are made – the weight comes back. The medicine does not solve the cause of obesity. Obesity is a disease when you stop treatment and do not change your lifestyle, the weight will rise again.”

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Facebook’s Zuckerberg targeted in US privacy lawsuit

Facebook founder Mark Zuckerberg was named personally in a Washington lawsuit Monday alleging he played a direct role in decisions that set the stage for the Cambridge Analytica privacy scandal.

The US capital’s attorney general argues that Zuckerberg was closely involved in conceiving the framework that allowed the Britain-based consulting firm to harvest over 70 million US Facebook users data.

A whistleblower revealed in 2018 that Cambridge Analytica went on to use that data for political purposes, including trying to rally support for Donald Trump.

“Zuckerberg is not just a figurehead at Facebook; he is personally involved in nearly every decision the company makes,” Washington Attorney General Karl Racine wrote in the suit.

He added that Zuckerberg’s control is baked into the structure of the company, where the founder and CEO holds a majority of voting shares.

Racine’s office sued Facebook over its data privacy practices in 2018 as part of a case that is ongoing.

Facebook’s parent company Meta did not immediately respond to the new lawsuit’s allegations, but spokesman Andy Stone noted on Twitter that a judge had previously rejected Racine’s bid to add Zuckerberg as a defendant in the privacy case.

US authorities imposed what they described as a “historic” $5 billion fine on Facebook in the wake of the scandal, and also required Facebook to ramp up privacy protections, provide detailed quarterly reports on compliance with the deal, and have an independent oversight board.

Since the Cambridge Analytica scandal broke, Facebook has removed access to its data from thousands of apps suspected of abusing it, restricted the amount of information available to developers in general, and made it easier for users to calibrate restrictions on personal data sharing.

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’End of an era’ as New York removes last of its iconic payphone booths

Marking the end of an era, New York City on Monday removed the last of its storied payphone booths, which have fallen victim to the ubiquity of free Wi-fi and cell phones in recent years.

But Superman fans can take comfort in the fact that Manhattan will keep four of the defunct booths, made famous as the impromptu changing rooms for journalist Clark Kent as he transformed into the Man of Steel.

Over the decades, the phone booths have featured widely in pop culture, from comic books to Hollywood blockbusters and TV shows.

That ended Monday morning, when, in front of assembled media, Manhattan borough president — the equivalent of the mayor — Mark Levine had the last booth housing two Bell System payphones at the corner of 7th Avenue and 50th Street dismantled and lifted on to a flatbed truck.

Levine said on Twitter he was “on hand today to say ‘Bye Bye’ one last time to the famed (infamous?) NYC pay phone.”

“I won’t miss all the dead dial tones but gotta say I felt a twinge of nostalgia seeing it go,” he added.

Fixed-line payphones began disappearing from the streets of New York in the early 2000s as cell phone use spread, and then vanished even faster in the 2010s with the explosion of smartphones.

The final blow came when, in 2015, Manhattan went ahead with the installation of thousands of LinkNYC hotspots offering WiFi and free local calls.

Those new kiosks are to be gradually connected to the emerging 5G network.

“Truly the end of an era but also, hopefully, the start of a new one with more equity in technology access,” said Levine, referring to neighborhoods in northern Manhattan, such as Harlem, that are less well covered by telephone and Internet networks.

According to local media, Manhattan will keep four of the old-fashioned phone booths on the Upper West Side, on West End Avenue at 66th, 90th, 100th and 101st streets.

’End of an era’ as New York removes last of its iconic payphone booths

’End of an era’ as New York removes last of its iconic payphone booths

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“Amazon” plants surveillance cameras for its drivers

It was reported that the American company “Amazon” is putting artificial intelligence-powered cameras in its delivery trucks in Britain
The move comes after the cameras were first introduced in America last year, according to a report from the British newspaper, The Telegraph.
The cameras monitor the performance of drivers on the road, and sound alerts if they are going fast or brake sharply, and the company will put assessments for them based on that, according to the British newspaper, “The Telegraph”.
Secret documents obtained by The Telegraph showed that Amazon created a points-based system to detect if drivers’ eyes were off the road, swaying or even sneezing.
Two cameras are installed in Amazon trucks in Britain, one facing the driver and the other facing the road.

Privacy activists considered the new “Amazon” cameras as “scary” and “intrusive”.
Silky Carlo, director of the UK-based Privacy Campaigns group, said: “Amazon has a track record of extensively monitoring low-paid people using often highly imprecise spying techniques, and then using that data to their disadvantage.”
“This kind of targeted surveillance can actually distract drivers, let alone demoralize them,” Carlo added. “It’s harmful to workers’ rights and intimidating privacy.”
And the report of the newspaper “The Telegraph” indicated that “Amazon” used the cameras in America to determine the salaries of drivers, and whether they would keep them or not.
An Amazon spokesperson told The Telegraph: “The purpose of introducing this technology is to keep drivers and communities safe, and there is no other reason behind that.”
He stressed that the company has conducted a comprehensive assessment of data privacy, in line with applicable laws.

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