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Wegovi medicine is a revolution in the treatment of obesity…. Information you must know before using it

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Wegovi’s weight-loss drug was approved by the US Food and Drug Administration (FDA) at the end of last week, describing the move as a “game changer”.

The drug, Wegovy, is used as a treatment to control weight loss, as it is injected weekly under the skin and is manufactured by the Danish pharmaceutical company Novo Nordisk.
Although this is the first FDA-approved weight-loss drug since 2014, it’s not exactly a new drug.

The same drug, also called semaglutide, has been used for years in the United States and elsewhere as an anti-diabetic drug. However, recent studies have shown that the drug, at a different and higher dosage, also acts as a powerful and effective appetite suppressant.

According to the Hebrew “Walla” website, the discovery of the long-term effects of the drug did not begin in one day, and the pharmaceutical companies that produced the smaglutide drug noted that while treating diabetic patients, patients lost weight.

The drug was usually administered to diabetic patients via moderate 3-4kg drops, leading the researchers to question whether the active ingredient could be used in higher doses. These drugs have been tested in large studies, and in addition to weight loss they have been found to reduce morbidity and mortality from cardiovascular disease.

In a study published earlier this year involving nearly 2,000 obese adults from 16 different countries, researchers reported that long-term treatment with the drug resulted in an average weight loss of about 15 percent in the group. Some of the participants even lost more weight, with more than 30 percent of the group losing more than 20 percent of their body weight – results that scientists describe as staggering.
How does Wegovi work?

“The Wigovy syringe given once a week works on several levels,” explains Dr. Alex Gorstein, an expert in endocrinology and diabetes at the Endocrinology Institute at Beilinson Hospital near Tel Aviv.

He added, “The first level is by increasing the secretion of insulin and suppressing appetite by affecting the satiety center. The second is to delay the passage of food through the stomach (this is important for diabetics). In addition, the drug has an anti-inflammatory effect. Nothing yet, but there are many drugs from the same family marketed under different names that we’ve been using for diabetes for a few years now.”
Who Can Medication Wegovee?

“Patients with a BMI greater than 30% or patients with a BMI greater than 27% and suffering from comorbidities such as fatty liver, blood pressure, diabetes, etc.”
Who can not use the drug?

Dr. Gorstein explains: “The drug may not be suitable for everyone. It is forbidden for patients with a previous history of pancreatitis, for patients with rare thyroid cancer or a related genetic syndrome, and for people who have problems with pancreatitis. If you have a chronic stomachache, we tend to be careful too.”
How much time do we need to see results?

“Results come quickly, within 10-12 weeks. The decrease in appetite occurs faster and within a month or two a person begins to lose weight.

Gorstein says that if a patient has not lost five percent of their weight after 3 months they should stop using the drug because it actually shows it isn’t right for them.
Do Wegove injections have side effects?

Most side effects are in the digestive system, and include symptoms such as nausea, abdominal discomfort, diarrhea or constipation. That is why we start with a small dose of the drug and increase the dose according to tolerance and side effects.

Side effects of the drug are common, and between 25-50 percent of patients experience them. These are mostly temporary symptoms that improve over time, and less than 10 percent stop treatment due to side effects.
What happens if you stop using it?

“This medication does not replace lifestyle changes such as eating a balanced diet and exercising,” Gorsain stresses.

“Once the treatment is stopped and no real changes are made – the weight comes back. The medicine does not solve the cause of obesity. Obesity is a disease when you stop treatment and do not change your lifestyle, the weight will rise again.”

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Hundreds of migrating songbirds crash into NYC skyscrapers

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Hundreds of birds migrating through New York City this week died after crashing into the city’s glass towers, a mass casualty event spotlighted by a New York City Audubon volunteer’s tweets showing the World Trade Center littered with bird carcasses.

This week’s avian death toll was particularly high, but bird strikes on Manhattan skyscrapers are a persistent problem that NYC Audubon has documented for years, said Kaitlyn Parkins, the group’s associate director of conservation and science.

Stormy weather Monday night into Tuesday contributed to the deaths, she said.

“We had a big storm and sort of weird weather and lots of birds, and that’s sort of the perfect combination that can lead to bird-window collisions,” Parkins said.

“It seems that the storm might have brought the birds in lower than they would have otherwise have been, or just disoriented them,” Parkins added. “The effects of nocturnal light on birds is also quite strong, especially when it’s a cloudy night.”

Volunteers with NYC Audubon document bird deaths at high-risk spots during the spring and fall migrations.

Melissa Breyer, the volunteer who tweeted about finding nearly 300 birds on sidewalks surrounding the new World Trade Center towers, said the experience was “overwhelming.”

“As soon as I got to the buildings, the birds were everywhere on the sidewalk,” Breyer said. “Looking north, covered, south, covered, west, covered, the sidewalks were literally covered with birds.”

NYC Audubon wants the owners of the World Trade Center towers and other buildings to help reduce the number of bird strikes by dimming the lights at night and by treating glass to make it more visible to birds.

“Make it so that they can see it and recognize that it’s a solid barrier that they cannot fly through,” Parkins said.

Jordan Barowitz, a spokesperson for the Durst Organization, co-developer of One World Trade Center, said in an email, “The first 200 feet of One WTC are encased in glass fins that are non-reflective. This design was chosen because it greatly reduces bird strikes which mostly occur below 200 feet and are frequently caused by reflective glass.”

Dara McQuillan, a spokesperson for Silverstein Properties, the developer of three other trade center skyscrapers, said, “We care deeply for wild birds and protecting their habitat in the five boroughs. Understanding that artificial night-time lighting in general can attract and disorient migrating birds, we are actively encouraging our office tenants to turn off their lights at night and lower their blinds wherever possible, especially during the migratory season.”

It wasn’t the last flight for all the birds that crashed. Some survived.

A total of 77 birds were taken to the Wild Bird Fund’s rehab facility on the Upper West Side on Tuesday, the majority of them from the trade center area, director Ritamary McMahon said.

“We knew it was going to be a large migration coming in. They could tell from the radar,” said McMahon, who scheduled extra staff to care for an expected influx of injured birds.

The Wild Bird Fund staff members gave the birds food, fluids and anti-inflammatory medications to reduce swelling.
Thirty birds recovered and were released in Brooklyn’s Prospect Park on Wednesday, McMahon said.

“One of our staff took an Uber down to Prospect Park to release them so they wouldn’t face any more tall buildings on their travels,” she said.

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Cyprus recovers looted 18th century church doors from Japan

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Cyprus’ Orthodox Church formally took charge Thursday of two ornately decorated 18th century doors stolen from a church in the ethnically divided island’s breakaway north and reclaimed from a Japanese art college after a long legal battle.

Communications and Works Minister Yiannis Karousos said the wooden doors — painted with religious scenes, carved and gilded — were discovered at the Kanazawa Art College more than 20 years ago and their return followed “long and intensive efforts.”

No information was provided on how the college acquired them.

The artifacts originally stood in the central gateway of the iconostasis — the ornately decorated screen that separates the sanctuary from the rest of an Orthodox church — of Saint Anastasios in Peristeronopigi village.

Built in 1775, the church sits atop a cave where the saint’s grave is preserved.

The doors were stolen after the island’s ethnic split in 1974, when Turkey invaded in response to a coup aimed at union with Greece. Turkish Cypriots declared independence in the north, that’s recognized only by Turkey.

In what Karousos called “cultural genocide,” hundreds of frescoes, mosaics and other religious works of art were looted from churches in the north after the invasion.

Since 1974, Cypriot government and church authorities have fought long legal battles in the United States, Europe and elsewhere to reclaim them.

Karousos said the doors’ repatriation sends the message to antiquities smugglers and “the international ring of crooks that however many years go by, (Cyprus) will hunt them down, because cultural genocide cannot be tolerated anywhere in the world.”

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French court lowers Bloomberg fine over hoax Vinci statement

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A French appeal court on Thursday upheld a ruling by France’s markets watchdog AMF against US news agency Bloomberg for publishing a hoax press release, French media reported, but lowered its fine to three million euros.

Bloomberg News was originally fined five million euros ($5.9 million) in December 2019 for publishing a hoax press release in November 2016 relating to construction group Vinci, which had filed a legal complaint to the AMF.

The AMF said at the time that Bloomberg should have known the information in the hoax press release was false.

“Our journalists, among others, simply reported on what appeared to be newsworthy information and were the victims of a sophisticated hoax, the perpetrator of which has not yet been found,” a Bloomberg spokesperson said after Thursday’s ruling.

“We hoped that the court would recognize the issues of press freedom at stake. We are disappointed the court has not overturned the original decision and will consider our options on appeal,” they added.

Vinci shares fell as much as 18 percent on Nov. 22, 2016 after the hoax statement, which said that the French group would revise its 2015 and 2016 accounts and fire its chief financial officer.

The AMF had said it had taken action against Bloomberg because it had published the statement without verifying it.

Vinci’s share price recovered after the company denied the Bloomberg report and said that the statement was a hoax.

The appeal court’s ruling was not immediately available on its website or on the AMF’s own site.

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